The Pathways Study: A Prospective Study of Breast Cancer Survivorship within Kaiser Permanente Northern California
Identifieur interne : 006910 ( Main/Exploration ); précédent : 006909; suivant : 006911The Pathways Study: A Prospective Study of Breast Cancer Survivorship within Kaiser Permanente Northern California
Auteurs : Marilyn L. Kwan [États-Unis] ; Christine B. Ambrosone [États-Unis] ; Marion M. Lee [États-Unis] ; Janice Barlow [États-Unis] ; Sarah E. Krathwohl [États-Unis] ; Isaac Joshua Ergas [États-Unis] ; Christine H. Ashley [États-Unis] ; Julie R. Bittner [États-Unis] ; Jeanne Darbinian [États-Unis] ; Keren Stronach [États-Unis] ; Bette J. Caan [États-Unis] ; Warren Davis [États-Unis] ; Susan E. Kutner [États-Unis] ; Charles P. Quesenberry [États-Unis] ; Carol P. Somkin [États-Unis] ; Barbara Sternfeld [États-Unis] ; John K. Wiencke [États-Unis] ; Shichun Zheng [États-Unis] ; Lawrence H. Kushi [États-Unis]Source :
- Cancer causes & control : CCC [ 0957-5243 ] ; 2008.
Abstract
With 2.3 million breast cancer survivors in the U.S. today, identification of modifiable factors associated with breast cancer recurrence and survival is increasingly important. Only recently new studies have been designed to examine the impact of lifestyle factors on prognosis, including Pathways, a prospective study of women with breast cancer in Kaiser Permanente Northern California (KPNC).
Pathways aims to examine the effect on recurrence and survival of 1) lifestyle factors such as diet, physical activity, quality of life, and use of alternative therapies and 2) molecular factors such as genetic polymorphisms involved in metabolism of chemotherapeutic agents. Eligibility includes any woman diagnosed with invasive breast cancer within KPNC, no previous diagnosis of other invasive cancer, age 21 years or older, and ability to speak English, Spanish, Cantonese, or Mandarin. Newly-diagnosed patients are identified daily from electronic pathology records and are enrolled within two months of diagnosis. An extensive baseline interview is conducted, blood and saliva samples are collected, and body measurements are taken. Women are followed for lifestyle updates, treatment, and outcomes by self-report and query of KPNC databases.
Recruitment began in January 9, 2006, and as of January 16, 2008, 1,539 women have been enrolled along with collection of 1,323 blood samples (86%) and 1,398 saliva samples (91%).
The Pathways Study will become a rich resource to examine behavioral and molecular factors and breast cancer prognosis.
Url:
DOI: 10.1007/s10552-008-9170-5
PubMed: 18478338
PubMed Central: 2581640
Affiliations:
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Le document en format XML
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<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">With 2.3 million breast cancer survivors in the U.S. today, identification of modifiable factors associated with breast cancer recurrence and survival is increasingly important. Only recently new studies have been designed to examine the impact of lifestyle factors on prognosis, including Pathways, a prospective study of women with breast cancer in Kaiser Permanente Northern California (KPNC).</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Pathways aims to examine the effect on recurrence and survival of 1) lifestyle factors such as diet, physical activity, quality of life, and use of alternative therapies and 2) molecular factors such as genetic polymorphisms involved in metabolism of chemotherapeutic agents. Eligibility includes any woman diagnosed with invasive breast cancer within KPNC, no previous diagnosis of other invasive cancer, age 21 years or older, and ability to speak English, Spanish, Cantonese, or Mandarin. Newly-diagnosed patients are identified daily from electronic pathology records and are enrolled within two months of diagnosis. An extensive baseline interview is conducted, blood and saliva samples are collected, and body measurements are taken. Women are followed for lifestyle updates, treatment, and outcomes by self-report and query of KPNC databases.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Recruitment began in January 9, 2006, and as of January 16, 2008, 1,539 women have been enrolled along with collection of 1,323 blood samples (86%) and 1,398 saliva samples (91%).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The Pathways Study will become a rich resource to examine behavioral and molecular factors and breast cancer prognosis.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Kwan, Marilyn L" sort="Kwan, Marilyn L" uniqKey="Kwan M" first="Marilyn L." last="Kwan">Marilyn L. Kwan</name>
</region>
<name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name>
<name sortKey="Ashley, Christine H" sort="Ashley, Christine H" uniqKey="Ashley C" first="Christine H." last="Ashley">Christine H. Ashley</name>
<name sortKey="Barlow, Janice" sort="Barlow, Janice" uniqKey="Barlow J" first="Janice" last="Barlow">Janice Barlow</name>
<name sortKey="Bittner, Julie R" sort="Bittner, Julie R" uniqKey="Bittner J" first="Julie R." last="Bittner">Julie R. Bittner</name>
<name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J." last="Caan">Bette J. Caan</name>
<name sortKey="Darbinian, Jeanne" sort="Darbinian, Jeanne" uniqKey="Darbinian J" first="Jeanne" last="Darbinian">Jeanne Darbinian</name>
<name sortKey="Davis, Warren" sort="Davis, Warren" uniqKey="Davis W" first="Warren" last="Davis">Warren Davis</name>
<name sortKey="Ergas, Isaac Joshua" sort="Ergas, Isaac Joshua" uniqKey="Ergas I" first="Isaac Joshua" last="Ergas">Isaac Joshua Ergas</name>
<name sortKey="Krathwohl, Sarah E" sort="Krathwohl, Sarah E" uniqKey="Krathwohl S" first="Sarah E." last="Krathwohl">Sarah E. Krathwohl</name>
<name sortKey="Kushi, Lawrence H" sort="Kushi, Lawrence H" uniqKey="Kushi L" first="Lawrence H." last="Kushi">Lawrence H. Kushi</name>
<name sortKey="Kutner, Susan E" sort="Kutner, Susan E" uniqKey="Kutner S" first="Susan E." last="Kutner">Susan E. Kutner</name>
<name sortKey="Lee, Marion M" sort="Lee, Marion M" uniqKey="Lee M" first="Marion M." last="Lee">Marion M. Lee</name>
<name sortKey="Quesenberry, Charles P" sort="Quesenberry, Charles P" uniqKey="Quesenberry C" first="Charles P." last="Quesenberry">Charles P. Quesenberry</name>
<name sortKey="Somkin, Carol P" sort="Somkin, Carol P" uniqKey="Somkin C" first="Carol P." last="Somkin">Carol P. Somkin</name>
<name sortKey="Sternfeld, Barbara" sort="Sternfeld, Barbara" uniqKey="Sternfeld B" first="Barbara" last="Sternfeld">Barbara Sternfeld</name>
<name sortKey="Stronach, Keren" sort="Stronach, Keren" uniqKey="Stronach K" first="Keren" last="Stronach">Keren Stronach</name>
<name sortKey="Wiencke, John K" sort="Wiencke, John K" uniqKey="Wiencke J" first="John K." last="Wiencke">John K. Wiencke</name>
<name sortKey="Zheng, Shichun" sort="Zheng, Shichun" uniqKey="Zheng S" first="Shichun" last="Zheng">Shichun Zheng</name>
</country>
</tree>
</affiliations>
</record>
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